BIOPHARMACEUTICAL STUDY OF BINARY POLOXAMER SYSTEMS AS IN SITU DRUG DELIVERY SYSTEMS POLOXAMER POLYCOMPLEXES: THE STUDY
نویسندگان
چکیده
Objective: The article presents the results of studying parameters in situ systems based on poloxamers. Methods: Natural, synthetic and semi-synthetic polymers were considered as additional gel-forming agents. above-mentioned agents cellulose derivatives, well rare-cross-linked acrylic polymers, alginic acid salts, xanthan gum. gelation temperature was visually recorded during gradual heating. Mucoadhesion determined by measuring separation force sample from mucosal model using pig stomach mucin. concentration gel formation an Ostwald capillary viscometer. Results: During experiment, 20 samples poloxamer 407 18% examined with addition excipients concentrations 0.5-2.0%. It found that introduction has a positive effect mucoadhesive properties 407. To increase binary mixture, it is necessary to take into account own introduced polymer, which confirmed viscometry. Also, viscometric studies revealed reasons for absence thermoreversible composition gum its use excipient matrix impractical. Composition best-investigated biopharmaceutical properties-the HEC 0.5% Conclusion: obtained can be explained fact when polymer exceeded, mixtures showed decrease up complete loss ability temperature-dependent sol-gel transition. choice agent improve system should some specific affect system.
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2022
ISSN: ['0975-7058']
DOI: https://doi.org/10.22159/ijap.2022v14i3.43930